Giorgio Biasiotto, Isabella Zanella, Federica Predolini, Ivonne Archetti, Moris Cadei, Eugenio Monti, Marcello Luzzani, Barbara Pacchetti, Paola Mozzoni and Roberta Andreoli
Synopsis
“Lignans are expected to have beneficial effects in humans after fermentative conversion in the colon to bioactive metabolites that may favourably influence parameters related to the metabolic syndrome( Reference Xu, Liu and Zhang27 ). Here we studied the effects of 7-HMR and TEP (a mixture of 7-HMR and allo-HMR) from P. abies as anti-obesity compounds at doses that can be reached through nutraceutical supplementation or approached with a lignan-rich diet( Reference O’Neill, Bohl and Gregersen28 )“We also found that total fat and isolated epididymal and gluteal fat pads were significantly smaller in the 7-HMR- and TEP-treated mice”“7-HMR and TEP lowered the lipid content in the liver”
Analysis
In 2018, one of the definitive studies on the lignan 7-hydroxymatairesinol was published in the British Journal of Nutrition, detailing the impact of this lignan on health. Lowering LDL’s visceral fat, and fatty deposits on the liver while lowering insulin resistance were key takeaways from this study.
